Technetium-99m
Target Material Mo-100 (1.0-1.6 g)
Target Backing Copper or Tantalum
Standard Target Dimensions Copper: Ø24 x 1 mm; Ø 28 x 1 mm Tantalum: ACSI TR24 Capsule; Custom sizes available
Target Fabrication By ARTMS
Coated diameter Ø18 mm (Coin targets), ~20 cm x ~60 cm (depending on target configuration)
Tested Current 500 μA (130 μA on coin targets)
Optimal Irradiation Energy 16 MeV (acceptable energy 15-24 MeV)
Target Yields ~39 Ci @ EOB (24 MeV, 500 μA, 6 h) ~13.9 Ci @ EOB (18 MeV, 300 μA, 6 h) ~4.7 Ci @ EOB (16.5 MeV, 130 μA, 6 h)
Radionuclidic purity >99.9% Tc-99m Meets all required radionuclidic purity requirements for injectable Tc-99m products
Chemical Purity < 10 ppm Aluminum < 30 ppm Molybdenum < 50 ppm Hydrogen Peroxide Meets all chemical purity requirements for injectable sodium pertechnetate
Shelf-life 24 h**
Product pH 4.5-7.5
Synthesis time: (EOB to NaTcO4) < 2 h

* Targets have not been tested to limits, they have been successfully tested to 130 and 500 μA. We are working to establish maximum currents.
** Establishing shelf-life of NaTcO4 is currently under development; labelling efficiency of individual kits may vary

Clinical Trial ‘A Blind Study Evaluating the Accuracy and Safety of Cyclotron-produced 99mTc in Adult Patients’ (NTC02514187) Completed

 

Publication:

Study Drug:

Study Focus:

Direct Production of 99mTc

via 100Mo(p,2n)

on Small Medical Cyclotrons

NaTcO4 and MDP

30/30 bone patients scanned

30/30 thyroid patients scanned

Patient clinical trial with demonstrated clinical equivalency between generation based Tc99m and

cyclotron produced Tc99m 1W scans for both bone and thyroid pts.

Targets used in the production of Technetium-99m from Cyclotron - ARTMS Products
Targets used in the production of Gallium-68 - ARTMS Products
Gallium-68

Target Material

Zn-68 (250-300 mg)

Target Backing

Silver or Aluminum

Standard target dimensions

Ø24 mm x 1.5 mm; Ø28 mm x 1.5 mm; Custom sizes available

Target Fabrication

By ARTMS

Coated Diameter

Ø10 mm

Tested Current

50 μA*

Optimal Irradiation Energy

12.7 MeV (acceptable 8-13 MeV)

Standard Target Yields

> 5 Ci (>180 GBq) @ EOB (12.8 MeV, 1 h, 50 μA)

> 2 Ci (>75 GBq) @ EOB (11.0 MeV, 1 h, 50 μA)

Preliminary Shelf life

>5 hours after EOB

Synthesis time:

(EOB to [68Ga]GaCl3)

< 1 h

 

* Targets have not been tested to limits, they have successfully been tested to 50 μA. We are working to establish maximum currents.

Copper-64

Target Material

Ni-64 (20-100+ mg)

Target Backing

Rhodium

Standard Target Dimensions

Ø 24 mm x 1 mm; Custom sizes available

Target Fabrication

By Customer (electroplating cell and process provided by ARTMS)

Ni-64 Electroplating Time

<24 h (<12 h typical, <4 for thin targets)

Plated density

>5 g/cm3

Coated diameter

Ø10 mm (Custom available)

Tested Current

65 µA

Optimal Irradiation Energy

11 MeV (acceptable energy <13 MeV)

Standard Target Yields

Depends on Target Mass

~450 mCi (~16.6 GBq) @ EOB

(60 mg target 100 μAh, 13 MeV)

Preliminary Radionuclidic

purity

2 h after EOB

~99.0% Cu-64 @ EOS (~2 h after EOB)

<1.0% Co-61 @ EOS (~2 h after EOB)

Results are preliminary and based on <12.9 MeV incident energy. Subject to change after further data collection.

Specific activity

>70 MBq/nmol (>70 GBq/μmol)

pH (Standard [64Cu]CuCl2 in HCl)

1-3

Synthesis time:

(EOB to [64Cu]CuCl2)

< 3 h

* Targets have not been tested to limits, they have been successfully tested to 65 μA. We are working to establish maximum currents.

Targets used in the production of Copper-64 - ARTMS Products
Targets used in the production of Zirconium-89 - ARTMS Products
Zirconium-89

Target Material

Y-89 (200-220 mg)

Target Backing

Tantalum or Niobium

Standard Backing Dimensions

Ø24 x 1 mm; Ø28 x 1 mm; Custom sizes available

Target Fabrication

By ARTMS

Coated Diameter

Standard: Ø10 mm; (Ø12 mm; Ø15 mm or custom

available)

Tested Current

50 μA*

Optimal Irradiation Energy

13 MeV (acceptable 8-13 MeV)

Standard Target Yields

13 MeV: >150 mCi (>5 GBq) @ EOB (6 h, 50 μA)

Preliminary Radionuclidic

Purity

Data coming soon.

Results are preliminary and are subject to change

after further data collection.

Synthesis time:

(EOB to [89Zr]ZrCl3)

< 1 h**

* Targets have not been tested to limits, they have successfully been tested to 50 μA. We are working to establish maximum currents.

** ARTMS purification is in development.

Certifications